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Adherence and Support
Interventions are needed to reduce drug resistance, particularly among those who are treatment naïve. Third line regimens may be needed in some resource limited settings. A systematic review was done on studies published on the spread of drug resistance in resource-limited settings after rollout of ART from 2001 to 2011, which reported on changes in the rate of HIV-1 drug resistance in treatment-naïve HIV-positive patients. The review found that east Africa had the highest rate of increase of drug resistance in treatment-naïve patients at 29% per year since rollout, followed by 14% in southern Africa, and 3% in west and central Africa. No specific analysis was done on gender because many studies did not include sex ratios. In total, 162 reports were included with data from 42 countries and 26,102 patients. In another study of Latin America, it was estimated that at least 6% of patients would need third line regimens within 5 years of ART initiation.
Adherence and Support
1 study